Efficient approach for determining four-dimensional computed tomography-based internal target volume in stereotactic radiotherapy of lung cancer
- Authors
- Yeo, Seung-Gu; Kim, Eun Seog
- Issue Date
- Dec-2013
- Publisher
- Korean Society for Therapeutic Radiology and Oncology
- Keywords
- Four-dimensional computed tomography; Internal target volume; Lung cancer; Stereotactic body radiotherapy
- Citation
- Radiation Oncology Journal, v.31, no.4, pp 247 - 251
- Pages
- 5
- Journal Title
- Radiation Oncology Journal
- Volume
- 31
- Number
- 4
- Start Page
- 247
- End Page
- 251
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13185
- DOI
- 10.3857/roj.2013.31.4.247
- ISSN
- 2234-1900
2234-3156
- Abstract
- Purpose: This study aimed to investigate efficient approaches for determining internal target volume (ITV) from four-dimensional computed tomography (4D CT) images used in stereotactic body radiotherapy (SBRT) for patients with early-stage non-small cell lung cancer (NSCLC). Materials and Methods: 4D CT images were analyzed for 15 patients who received SBRT for stage I NSCLC. Three different ITVs were determined as follows: combining clinical target volume (CTV) from all 10 respiratory phases (ITV10Phases); combining CTV from four respiratory phases, including two extreme phases (0% and 50%) plus two intermediate phases (20% and 70%) (ITV4Phases); and combining CTV from two extreme phases (ITV2Phases). The matching index (MI) of ITV4Phases and ITV(2Phase)s was defined as the ratio of ITV4Phases and ITV2Phases, respectively, to the ITV10Phases. The tumor motion index (TMI) was defined as the ratio of ITV10Phases to CTVmean, which was the mean of 10 CTVs delineated on 10 respiratory phases. Results: The ITVs were significantly different in the order of ITV10Phases, ITV4Phases, and ITV2Phases (all p < 0.05). The MI of ITV(4Phase)s was significantly higher than that of ITV2Phases (p < 0.001). The MI of ITV4Phases was inversely related to TMI (r = -0.569, p = 0.034). In a subgroup with low TMI (n = 7), ITV4Phases was not statistically different from ITV10Phases (p = 0.192) and its MI was significantly higher than that of ITV2Phases (p = 0.016). Conclusion: The ITV4Phases may be an efficient approach alternative to optimal ITV10Phases in SBRT for early-stage NSCLC with less tumor motion.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Radiation Oncology > 1. Journal Articles
- College of Medicine > Department of Radiation Oncology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13185)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.