tert-Butylhydroquinone reduces lipid accumulation in C57BL/6 mice with lower body weight gain
- Authors
- Nam, Kung-Woo; Kim, Yong Hyun; Kwon, Hyun Jung; Rhee, Sang-Ki; Kim, Wan-Jong; Han, Man-Deuk
- Issue Date
- Jul-2013
- Publisher
- 대한약학회
- Keywords
- tert-Butylhydroquinone; ACOX1; Real-time RT-PCR; Obesity
- Citation
- Archives of Pharmacal Research, v.36, no.7, pp 897 - 904
- Pages
- 8
- Journal Title
- Archives of Pharmacal Research
- Volume
- 36
- Number
- 7
- Start Page
- 897
- End Page
- 904
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13554
- DOI
- 10.1007/s12272-013-0109-3
- ISSN
- 0253-6269
1976-3786
- Abstract
- tert-Butylhydroquinone (tBHQ) is a commonly used antioxidant additive that is approved for human use by both the Food and Agriculture Organization and the World Health Organization (FAO/WHO). In this study, we examined the effect of tBHQ on body weight gain and found that food supplementation with 0.001 % (w/w) tBHQ inhibited 61.4 % (P < 0.01) of body weight gain in high-fat diet (HFD)-induced C57BL/6 mice, and the oral administration of tBHQ (1.5 mg/kg) reduced 47.5 % (P < 0.05) of body weight gain in normal diet fed db/db mice. The HFD increased lipid deposit in adipocytes, but these were reduced significantly by tBHQ treatment in C57BL/6 mice. tBHQ supplementation significantly lowered the plasma triglyceride and total cholesterol, with reduced size of accumulated fat mass. The rate limiting enzyme of beta-oxidation (ACOX1) was significantly over-expressed in the liver with tBHQ treatment. These results indicate that tBHQ suppresses body weight gain in mice, possibly at least related to the up-regulation of ACOX1 gene expression.
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Collections - College of Natural Sciences > Department of Life Science and Biotechnology > 1. Journal Articles
- College of Natural Sciences > Department of Biology > 1. Journal Articles
- College of Medical Sciences > Department of Pharmaceutical Engineering > 1. Journal Articles
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