Japanese bog orchid (Eupatorium japonicum) extract suppresses expression of inducible nitric oxide synthase and cyclooxygenase-2 induced by toll-like receptor agonists
- Authors
- Gu, Gyo-Jeong; Eom, Sang-Hoon; Shin, Hwa-Jeong; Paek, Ji Hun; Kim, Songmun; Lim, Soon Sung; Youn, Hyung-Sun
- Issue Date
- Jun-2013
- Publisher
- 한국식품과학회
- Keywords
- Eupatorium japonicum; inflammation; nuclear factor-kappa B; cyclooxygenase-2; inducible nitric oxide synthase
- Citation
- Food Science and Biotechnology, v.22, no.3, pp 811 - 815
- Pages
- 5
- Journal Title
- Food Science and Biotechnology
- Volume
- 22
- Number
- 3
- Start Page
- 811
- End Page
- 815
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13644
- DOI
- 10.1007/s10068-013-0149-y
- ISSN
- 1226-7708
2092-6456
- Abstract
- Toll-like receptors (TLR) play an important role in the recognition of many pathogen-associated molecular patterns and the induction of innate immunity. Dysregulated activation of TLR signaling pathways is associated with certain inflammatory diseases. Japanese bog orchid (Eupatorium japonicum), which belongs to a family of Asteraceae plants, is consumed as a tea. The present study investigated the effect of the ethanol extracts of flowers of Japanese bog orchid (EJE) on nuclear factor (NF)-kappa B activation and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by TLR agonists in murine macrophages. EJE suppressed NF-kappa B activation and iNOS and COX-2 expression induced by lipopolysaccharide (TLR4 agonist), polyriboinosinic polyribocytidylic acid (TLR3), and macrophage-activating 2 kDa lipopeptide (TLR2 and TLR6). These results suggest that EJE can regulate TLR signaling pathways and indicated its potential as a potent anti-inflammatory drug.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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