Evaluation of vitamin D level in patients from neurosurgical intensive care unit star(.)
- Authors
- Yi, Ho Jun; Jeong, Je Hoon; Jin, Eun-Sun; Shin, Il Young; Hwang, Hyung Sik; Moon, Seung-Myung
- Issue Date
- Jun-2013
- Publisher
- Neural Regeneration Research
- Keywords
- neural regeneration; vitamin D; white blood cell; immune deficiency; infectious diseases; intensive care unit; neurosurgery; neuroregeneration
- Citation
- Neural Regeneration Research, v.8, no.16, pp 1528 - 1534
- Pages
- 7
- Journal Title
- Neural Regeneration Research
- Volume
- 8
- Number
- 16
- Start Page
- 1528
- End Page
- 1534
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13649
- DOI
- 10.3969/j.issn.1673-5374.2013.16.010
- ISSN
- 1673-5374
1876-7958
- Abstract
- Vitamin D plays an important role in maintaining normal bone metabolism. Recent studies have suggested that vitamin D influences many other physiological processes, including muscle function, cardiovascular homeostasis, nerve function, and immune response. Furthermore, accumulated evidence suggests that vitamin D also mediates the immune system response to infection. Critical neurosurgical patients have higher infection and mortality rates. To correlate vitamin D deficiency to the immunological status of neurosurgical intensive care unit patients, we detected serum vitamin D level in 15 patients with clinically suspected infection and 10 patients with confirmed infection. Serum level of 25-hydroxyvitamin D, the primary circulating form of vitamin D, was significantly decreased in patients with suspected or confirmed infection after a 2-week neurosurgical intensive care unit hospitalization, while serum level of 1,25-dihydroxyvitamin D, the active form of vitamin D, was significantly decreased in patients after a 4-week neurosurgical intensive care unit hospitalization. These findings suggest that vitamin D deficiency is linked to the immunological status of neurosurgical intensive care unit patients and vitamin D supplementation can improve patient's immunological status.
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- Appears in
Collections - College of Medicine > Department of Neurosurgery > 1. Journal Articles
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