Follow-up of primary Sjogren's syndrome patients presenting positive anti-cyclic citrullinated peptides antibody
- Authors
- Ryu, Yang-Seon; Park, Sung-Hwan; Lee, Jennifer; Kwok, Seung-Ki; Ju, Ji-Hyeon; Kim, Ho-Youn; Jeon, Chan-Hong
- Issue Date
- Jun-2013
- Publisher
- Springer Verlag
- Keywords
- Anti-CCP antibody; Primary Sjogren's syndrome; Rheumatoid arthritis
- Citation
- Rheumatology International, v.33, no.6, pp 1443 - 1446
- Pages
- 4
- Journal Title
- Rheumatology International
- Volume
- 33
- Number
- 6
- Start Page
- 1443
- End Page
- 1446
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13652
- DOI
- 10.1007/s00296-012-2572-4
- ISSN
- 0172-8172
1437-160X
- Abstract
- Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is very useful for the diagnosis of rheumatoid arthritis (RA) and is associated with articular erosions. The specificity of anti-CCP antibody in the diagnosis of RA has been reported to be about 95 %. Because of its higher specificity in RA, we assessed the clinical features of primary Sjogren's syndrome (pSS) who were positive for anti-CCP antibody. We assessed the clinical features of 405 pSS patients. After 60 (range 7-98) months, 23 (5.6 %) patients previously diagnosed with pSS had progressed to RA. Comparing the anti-CCP positive group with the negative group, laboratory test results for anti-CCP titer and rheumatoid factor positivity with respect to clinical outcome and progression to RA, arthralgia and arthritis were significantly different. Multivariate regression analysis also showed that anti-CCP antibody titer was independently associated with progression to RA. The odds ratio of anti-CCP positivity in terms of progression to RA was 2.5 (95 % CI 1.7-3.7). Testing for anti-CCP antibody in pSS patients with arthritis may allow for the prediction of progression to RA.
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