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Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists
- Authors
- Shin, Hwa-Jeong; Shon, Dong-Hwa; Youn, Hyung-Sun
- Issue Date
- Jan-2013
- Publisher
- Elsevier BV
- Keywords
- Inducible nitric oxide synthase; Inflammation; Isobavachalcone; Nuclear factor-kappa B; Toll-like receptors
- Citation
- International Immunopharmacology, v.15, no.1, pp 38 - 41
- Pages
- 4
- Journal Title
- International Immunopharmacology
- Volume
- 15
- Number
- 1
- Start Page
- 38
- End Page
- 41
- ISSN
- 1567-5769
1878-1705
- Abstract
- Toll-like receptors (TLRs) play an important role by recognizing many pathogen-associated molecular patterns and inducing innate immunity. Dysregulated activation of TLR signaling pathways induces the activation of various transcription factors such as nuclear factor-kappa B, leading to the induction of pro-inflammatory gene products such as inducible nitric oxide synthase (iNOS). The present study investigated the effect of isobavachalcone (IBC), a natural chalcone component of Angelica keiskei, on inflammation by modulating iNOS expression induced by TLR agonists in murine macrophages. IBC suppressed iNOS expression induced by macrophage-activating lipopeptide 2-kDa, polyriboinosinic polyribocytidylic acid, or lipopolysaccharide. These results indicate the potential of IBC as a potent anti-inflammatory drug. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
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Related Researcher
- youn, hyung sun
- College of Medical Sciences (Department of Biomedical Laboratory Science)