피하층 열상 쥐모델에서 Polydeoxyribonucleotide (PDRN)가 봉합치료에 미치는 효과Effectiveness of Polydeoxyribonucleotide (PDRN) Material on Murine Subcutaneous Laceration Wounds
- Other Titles
- Effectiveness of Polydeoxyribonucleotide (PDRN) Material on Murine Subcutaneous Laceration Wounds
- Authors
- 김재윤; 김호중; 이종빈; 성수동; 조영순
- Issue Date
- 2013
- Publisher
- 대한응급의학회
- Keywords
- PDRN; Polydeoxyribonucleotide; Subcutaneous; Laceration; Wound
- Citation
- 대한응급의학회지, v.24, no.4, pp.453 - 458
- Journal Title
- 대한응급의학회지
- Volume
- 24
- Number
- 4
- Start Page
- 453
- End Page
- 458
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14248
- ISSN
- 1226-4334
- Abstract
- Purpose: To evaluate the effectiveness of polydeoxyribonucleotide (PDRN) material on murine subcutaneous laceration wounds.
Methods: Subcutaneous laceration wounds were made on the back of mice. The mice were divided into two groups according to method of PDRN applied: Group I (control,general dressing, and management) and Group II (PDRN injection). We evaluated gross findings and histological findings for the groups.
Results: A total of 18 mice (9 in the Suture group and 9with Suture+PDRN) were enrolled. In the mean results of gross finding (5-point Likert scale), the mean gross findings for wounds in the PDRN group were significantly higher than the suture groups on post-operative day 4 and 7 (for day 4, Suture: 2, Suture+PDRN: 3.2; for day 7, Suture: 2.7,Suture+PDRN: 4.2; p<0.05). In the histological analysis of wounds in the Suture+PDRN group after 10 days, reepithelization and granulation tissue formation were better than the Suture group. In terms of wound-healing grade, reepithelization and inflammation were not different; however,in the Suture+PDRN group, more granulation tissue formation was noted compared to the Suture group (p<0.05). In addition, the expression of VEGF in the Suture+PDRN group significantly increased compared to the Suture group (Suture: 11170±2475, Suture + PDRN: 27243±6621,p<0.05).
Conclusion: The Suture+PDRN group can be used for the early treatment and histological healing of subcutaneous laceration wounds.
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