계피식물(Cinnamomum loureiroi)에서 분리한 coumarin과 유도체의 방오효과

Abstract

The active antifouling compounds coumarin and its derivatives were isolated from the cinnamon tree Cinnamomum loureiroi . The antifouling activities were determined using representative soft fouling organisms: the seaweed Ulvapertusa and diatom Navicula annexa . The chemical constituents with antifouling activities were identified as coumarin, hydroxylcoumarin, coumaric acid, and cinnamaldehyde by interpreting nuclear magnetic resonance, and high-resolution mass spectroscopy data. These compounds were isolated from 1.09 g of crude Cinnamomum sp.methanol extract, yielding approximately 18.4, 6.3, 9.8, and 14.7 mg of coumarin, hydroxylcoumarin, coumaric acid, and cinnamaldehyde, respectively. The compounds inhibited U . pertusa zoospores with EC50 values of 0.13-0.25 μg/mL, and the diatom N . annexa with EC50 of 0.21-0.81 μg/mL.