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Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
- Issue Date
- 30-Sep-2012
- Publisher
- 한국응용약물학회
- Keywords
- Rutaecarpine; Oxidative stress; DNA damage; Quinone reductase; Apoptosis; Hydrogen peroxide
- Citation
- Biomolecules & Therapeutics, v.20, no.5, pp 487 - 491
- Pages
- 5
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 20
- Number
- 5
- Start Page
- 487
- End Page
- 491
- ISSN
- 1976-9148
2005-4483
- Abstract
- The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide (H2O2) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by 500 mu M H2O2, as assessed by 4',6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting.
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Collections - College of Natural Sciences > Department of Biology > 1. Journal Articles
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Related Researcher
- Nam, Kung woo
- Industry-University Cooperation Foundation