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Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats
- Authors
- Nam, Sung Min; Yi, Sun Shin; Yoo, Dae Young; Kim, Woosuk; Choi, Jung Hoon; Hwang, In Koo; Seong, Je Kyung; Yoon, Yeo Sung
- Issue Date
- Aug-2012
- Publisher
- Maruzen Co., Ltd/Maruzen Kabushikikaisha
- Keywords
- cyclooxygenase-2; hippocampus; streptozotocin; type 1 diabetes
- Citation
- Journal of Veterinary Medical Science, v.74, no.8, pp 977 - 982
- Pages
- 6
- Journal Title
- Journal of Veterinary Medical Science
- Volume
- 74
- Number
- 8
- Start Page
- 977
- End Page
- 982
- ISSN
- 0916-7250
- Abstract
- In this study, we investigated diabetic stage dependent cyclooxygenase-2 (COX-2) immunoreactivity in the dentate gyrus in streptozotocin (STZ)-induced type 1 diabetic rats. The animals were sacrificed at 2,3 and 4 weeks after STZ treatment. Blood glucose levels were increased after STZ treatment. COX-2 immunoreactivity in dentate gyrus was significantly increased in these regions 3 weeks after STZ treatment and restored to its basal level to 4 weeks after STZ treatment. In contrast, COX-2 immunoreactivity was not changed in CA3 region in all groups. These results suggest that STZ-induced type 1 diabetes transiently, but not permanently, decreased synaptic transmission and plasticity 3 weeks after STZ treatment in the dentate gyrus.
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Related Researcher
- Yi, Sun Shin
- College of Medical Sciences (Department of Biomedical Laboratory Science)