Association of Glutathione S-transferase genes (GSTM1 and GSTT1) polymorphisms with hypertension in lead-exposed workers
- Authors
- Lee, Byung-Kook; Lee, Soo Jeong; Joo, Jae Soon; Cho, Kwang-Sung; Kim, Nam Soo; Kim, Hak-Jae
- Issue Date
- 30-Jun-2012
- Publisher
- 대한독성 유전단백체 학회
- Keywords
- Lead; Hypertension; Glutathione S-transferases (GSTs); GSTT1; GSTM1; Polymorphism
- Citation
- Molecular & Cellular Toxicology, v.8, no.2, pp 203 - 208
- Pages
- 6
- Journal Title
- Molecular & Cellular Toxicology
- Volume
- 8
- Number
- 2
- Start Page
- 203
- End Page
- 208
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15054
- DOI
- 10.1007/s13273-012-0025-5
- ISSN
- 1738-642X
2092-8467
- Abstract
- It is proposed that lead concentrations in the blood are related to intracellular glutathione and lead might be conjugated with glutathione non-enzymatically or enzymatically via glutathione S-transferase (GST). Essential hypertension is a complex, multifactorial and polygenic disease in which the underlying genetic components remain unknown. This study was aimed to investigate GST-mu1 (GSTM1) and GST-theta1 (GSTT1) gene polymorphisms in lead-exposed workers and their relationship with blood lead levels and lead-related hypertension. To address the possible association, GSTM1 and GSTT1 (homozygous deletion vs. non-deleted) polymorphisms in 755 lead-exposed male workers were analyzed. GSTM1 and GSTT1 polymorphisms were determined using a Multiplex PCR. We observed significant association in positive alleles of GSTT1 (OR = 1.593, 95% CI=.1..157-2.194). However, no significant association in GSTM1 was observed with lead-related hypertension. For combined analysis with GSTM1 and GSTT1 both positive type (+/+) and GSTT1 positive (-/+) group showed significant differences between groups. These data suggest that the GSTT1 positive type polymorphism might be associated with lead-related hypertension in the lead-exposed male workers.
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Collections - College of Medicine > Department of Clinical Pharmacology > 1. Journal Articles
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