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Allyl isothiocyanate suppresses lipopolysaccharide-induced expression of inducible nitric oxide synthase, but not induced expression of cyclooxygenase-2
- Authors
- Kim, Soo-Jung; Park, Hye-Jeong; Youn, Hyung-Sun
- Issue Date
- 30-Jun-2012
- Publisher
- 대한독성 유전단백체 학회
- Keywords
- Allyl isothiocyanate; Inflammation; Nuclear factor-kappa B; Cyclooxygenase-2; Inducible nitric oxide synthase
- Citation
- Molecular & Cellular Toxicology, v.8, no.2, pp 149 - 154
- Pages
- 6
- Journal Title
- Molecular & Cellular Toxicology
- Volume
- 8
- Number
- 2
- Start Page
- 149
- End Page
- 154
- ISSN
- 1738-642X
2092-8467
- Abstract
- The pathophysiological processes of inflammation are involved in numerous diseases including cancer. Dysregulated activation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases. Allyl isothiocyanate (AITC), which is present in many common cruciferous vegetables, has been used to treat many chronic diseases. The present study investigated the effect of AITC on lipopolysaccharide (LPS)-induced iNOS and COX-2 expression in marine macrophages. AITC suppressed LPS-induced iNOS expression, but did not suppress LPS-induced COX-2 expression, suggesting that AITC has a specific anti-inflammatory mechanism.
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Related Researcher
- youn, hyung sun
- College of Medical Sciences (Department of Biomedical Laboratory Science)