Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model
- Authors
- Jeong, Hoon Jae; Kim, Dae Won; Woo, Su Jung; Kim, Hye Ri; Kim, So Mi; Jo, Hyo Sang; Park, Meeyoung; Kim, Duk-Soo; Kwon, Oh-Shin; Hwang, In Koo; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Choi, Soo Young
- Issue Date
- May-2012
- Publisher
- 한국분자세포생물학회
- Keywords
- antioxidant; Parkinson disease; protein transduction; ROS; Tat-DJ-1
- Citation
- Molecules and Cells, v.33, no.5, pp 471 - 478
- Pages
- 8
- Journal Title
- Molecules and Cells
- Volume
- 33
- Number
- 5
- Start Page
- 471
- End Page
- 478
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15234
- DOI
- 10.1007/s10059-012-2255-8
- ISSN
- 1016-8478
0219-1032
- Abstract
- Parkinson's disease (PD) is a well known neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compact (SN). Although the exact mechanism remains unclear, oxidative stress plays a critical role in the pathogenesis of PD. DJ-1 is a multifunctional protein, a potent antioxidant and chaperone, the loss of function of which is linked to the autosomal recessive early onset of PD. Therefore, we investigated the protective effects of DJ-1 protein against SH-SY5Y cells and in a PD mouse model using a cell permeable Tat-DJ-1 protein. Tat-DJ-1 protein rapidly transduced into the cells and showed a protective effect on 6-hydroxydopamine (6-OHDA)-induced neuronal cell death by reducing the reactive oxygen species (ROS). In addition, we found that Tat-DJ-1 protein protects against dopaminergic neuronal cell death in 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP)-induced PD mouse models. These results suggest that Tat-DJ-1 protein provides a potential therapeutic strategy for against ROS related human diseases including PD.
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Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
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