Antiulcerogenic Activity of Scoparone on HCl/Ethanol-induced Gastritis in Rats
- Authors
- Choi, Won Sik; Jang, Do Yoen; Nam, Seok Woo; Park, Byeoung Soo; Lee, Hoi-Seon; Lee, Sung Eun
- Issue Date
- Apr-2012
- Publisher
- The Korean Society for Applied Biological Chemistry
- Keywords
- Artemisia capillaries; Hericium erinaceum gastritis; rat; scoparone
- Citation
- Journal of the Korean Society for Applied Biological Chemistry, v.55, no.2, pp 159 - 163
- Pages
- 5
- Journal Title
- Journal of the Korean Society for Applied Biological Chemistry
- Volume
- 55
- Number
- 2
- Start Page
- 159
- End Page
- 163
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15271
- DOI
- 10.1007/s13765-012-1023-y
- ISSN
- 1738-2203
- Abstract
- Protective effect of ethanol extract from Hericium erinaceus cultivated with Artemisia capillaries (HEAC) on gastric mucosal damage induced by 0.15 M HCl in ethanol in rats was evaluated. HEAC showed higher potent protective effect on gastritis with effective dose 50 (ED50) value of 22.6 mg/kg compared those of selbex and stillen at 46.5 and 44.2 mg/kg, respectively, the presently used medicines for treating gastritis. ichloromethane fraction showed a dose-dependent protective effect on gastritis with ED50 value of 18.1 mg/kg. The biologically active component of dichloromethane fraction derived from HEAC ethanolic extract was characterized by spectroscopic analysis as scoparone with protective rate of 93% and ED50 value of 4.2 mg/kg on gastritis. Taken together, administration of HEAC and scoparone provided protective effect on the gastric lesion induced by ethanol-HCl and may therefore be a promising drug for treatment of gastritis and gastric ulcer.
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Collections - College of Natural Sciences > Department of Life Science and Biotechnology > 1. Journal Articles
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