Gastrointestinal Metabolic Surgery for the Treatment of Diabetic Patients: A Multi-Institutional International Study
- Authors
- Lee, Wei-Jei; Hur, Kyung Yul; Lakadawala, Muffazal; Kasama, Kazunori; Wong, Simon K. H.; Lee, Yi-Chih
- Issue Date
- Jan-2012
- Publisher
- Springer Verlag
- Keywords
- Gastrointestinal metabolic surgery; Type 2 diabetes mellitus
- Citation
- Journal of Gastrointestinal Surgery, v.16, no.1, pp 45 - 51
- Pages
- 7
- Journal Title
- Journal of Gastrointestinal Surgery
- Volume
- 16
- Number
- 1
- Start Page
- 45
- End Page
- 51
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15473
- DOI
- 10.1007/s11605-011-1740-2
- ISSN
- 1091-255X
1873-4626
- Abstract
- Gastrointestinal metabolic surgery has been proposed for the treatment of not well-controlled type 2 diabetes mellitus (T2DM) patients with a body mass index (BMI) < 35 kg/m(2). This study aims to describe recent experience with surgical treatment of T2DM in Asian centers. Patients aged 20 to 70 years with not well-controlled T2DM [glycated hemoglobin (HbA1C) > 7.0%] and BMI < 35 kg/m(2) were included at five institutes between 2007 and 2010. The end point is T2DM remission, defined by fasting plasma glucose < 110 mg/dl and HbA1C < 6.0%. Of the 200 patients, 172 (86%) underwent gastric bypass, 24 (12%) underwent sleeve gastrectomy, and the other 4 underwent adjustable banding. Laparoscopic access was used in all the patients. Gender (66.5% female), age (mean 45.0 +/- 10.8), and HbA1C (mean 9.3 +/- 1.9%) did not differ between the procedure among the groups. Until now, 87 patients had 1-year data. One year after surgery, the mean BMI decreased from 28.5 +/- 3.0 to 23.4 +/- 2.3 kg/m(2) and HbA1C decreased to 6.3 +/- 0.5%. Remission of T2DM was achieved in 72.4% of the patients. Patients with a diabetes duration of < 5 years had a better diabetes remission rate than patients with duration of diabetes > 5 years (90.3% vs. 57.1%; p = 0.006). Patients with BMI > 30 kg/m(2) had a better diabetes remission rate than those with BMI < 30 kg/m(2) (78.7% vs. 62.5%; p = 0.027). Individuals who underwent gastric bypass loss more weight and had a higher diabetes remission rate than individuals who underwent restrictive-type procedures. Multivariate analysis confirmed that the duration of diabetes and the type of surgery predict the diabetes remission. No mortalities were reported and two (1.0%) patients had major morbidities. Gastrointestinal metabolic surgery is an effective treatment for not well-controlled T2DM treatment. Diabetes remission is significantly higher in those with duration of diabetes less than 5 years and BMI > 30 kg/m(2).
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Collections - College of Medicine > Department of General Surgery > 1. Journal Articles
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