Alteration in NCX-3 immunoreactivity within the gerbil hippocampus following spontaneous seizures
- Authors
- Park, Dae-Kyoon; Park, Kyung-Ho; Ko, Jeong-Sik; Kim, Duk-Soo
- Issue Date
- 31-May-2011
- Publisher
- 생화학분자생물학회
- Keywords
- Epilepsy; Gerbil; Hippocampus; Immunohistochemistry; Na+/Ca2+ exchanger (NCX)
- Citation
- BMB Reports, v.44, no.5, pp 306 - 311
- Pages
- 6
- Journal Title
- BMB Reports
- Volume
- 44
- Number
- 5
- Start Page
- 306
- End Page
- 311
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16534
- DOI
- 10.5483/BMBRep.2011.44.5.306
- ISSN
- 1976-6696
1976-670X
- Abstract
- Although NCX-3 is highly expressed in the brain, the distribution of NCX-3 in the epileptic hippocampus is still controversial. Therefore, to assess the distribution and pattern of NCX-3 expression in epileptic hippocampus, we performed a comparative analysis of NCX-3 immunoreactivities in the hippocampus of seizure-resistant (SR) and seizure-sensitive (SS) gerbils. In SR gerbils, NCX-3 immunoreactivity was higher than pre-seizure SS gerbils, particularly in the pavalbumin (PV)-positive interneurons. Three h post-ictal, NCX-3 immunoreactivity in the SS gerbil hippocampus was markedly elevated to the level of SR gerbils. Six h post-ictal, the expression of NCX-3 was reduced to the level of pre-seizure SS gerbils. Therefore, the results of the present study suggest that down-regulation of NCX-3 expression in the SS gerbil hippocampus may be involved in the hyperexcitability of SS gerbils due to an imbalance of intracellular Na+/Ca2+ homeostasis and Ca2+ concentration. [BMB reports 2011; 44(5): 306-311]
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