The Impact of Hyperuricemia on In-Hospital Mortality and Incidence of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention
- Authors
- Park, Sang-Ho; Shin, Won-Yong; Lee, Eun-Young; Gil, Hyo-Wook; Lee, Se-Whan; Lee, Seung-Jin; Jin, Dong-Kyu; Hong, Sae-Yong
- Issue Date
- Mar-2011
- Publisher
- Japanese Circulation Society/Nihon Junkanki Gakkai
- Keywords
- Ischemic heart disease; Kidney; Percutaneous coronary intervention; Renal failure
- Citation
- Circulation Journal, v.75, no.3, pp 692 - 697
- Pages
- 6
- Journal Title
- Circulation Journal
- Volume
- 75
- Number
- 3
- Start Page
- 692
- End Page
- 697
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16701
- DOI
- 10.1253/circj.CJ-10-0631
- ISSN
- 1346-9843
1347-4820
- Abstract
- Background: There is very little information about the relationship between hyperuricemia, acute kidney injury (AKI) and in-hospital mortality. Methods and Results: With a retrospective analysis of the medical records, 1,247 patients who had percutaneous coronary intervention (PCI) were investigated. AKI was defined as an increase in serum creatinine of >= 0.5 mg/dl or >= 50% over baseline within 7 days of PCI. The association of AKI with clinical, biochemical and procedural variables were examined. In addition, the association of hyperuricemia with in-hospital mortality was also examined. Of the 1,247 patients in the study population, 51 (4.1%) experienced AKI after PCI, 15 of whom required hemodialysis. In-hospital mortality occurred in 1.6% (20 of 1,247) in 19.6% (10 of 51) of AKI individuals, and 0.8% (10 of 1,186) of the non-AKI participants (odd ratios, 28.927; 95% confidence intervals, 11.411-73.328; P < 0.001). In our study, the most powerful predictors of these variables were acute myocardial infarction, baseline estimated glomerular filtration rate (eGFR) < 60 ml.min(-1).1.73m(-2), diabetics mellitus, anemia and hyperuricemia. Notably, the incidence of AKI after PCI markedly increased in diabetic or hyperuricemic patients with a baseline eGFR of < 60 ml.min(-1).1.73m(-2). Conclusions: It is clear that AKI develops due to multiple risk factors. Our results indicate that hyperuricemia is independently associated with an increased risk of in-hospital mortality and AKI in patients treated with PCI. (Circ J 2011; 75: 692 697)
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