Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs
- Authors
- Park, Kwisung; Song, Jaehyoung; Baek, Kyoungah; Lee, Changgyun; Kim, Donguk; Cho, SamHyun; Park, JoonSoo; Choi, YoungJin; Kang, Byunghak; Choi, Hwajung; Cheon, Doo-Sung
- Issue Date
- 24-Feb-2011
- Publisher
- BioMed Central
- Citation
- Virology Journal, v.8
- Journal Title
- Virology Journal
- Volume
- 8
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16704
- DOI
- 10.1186/1743-422X-8-79
- ISSN
- 1743-422X
- Abstract
- An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with aseptic meningitis, we performed sequencing of the Korean ECV 5 strain and compared it with a prototype strain (Noyce). At the nucleotide level, the P1 region (85.3%) had the highest identity value; at the amino acid level, the P3 region (98.0%) had the highest identity value. The two strains shared all cleavage sites, with the exception of the VP1/2A site, which was TY/GA in the Noyce strain but TR/GA in the Korean ECV 5 isolate. In Vero cells infected with the Korean ECV 5 isolate, no cytotoxicity was observed in the presence of azidothymidine, acyclovir, amantadine, lamivudine, or ribavirin, when the drugs were administered at a CC50 value > 100 mu g/mL. Of the five drugs, only amantadine (IC50: 1 +/- 0.42 mu g/mL, TI: 100) and ribavirin (IC50: 22 +/- 1.36 mu g/mL, TI: 4.55) had any antiviral activity against the Korean ECV 5 isolate.
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Collections - College of Medicine > Department of Clinical Pathology > 1. Journal Articles
- College of Medicine > Department of Pediatrics > 1. Journal Articles
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