In Vitro and In Vivo Evaluations of 3D Porous TCP-coated and Non-coated Alumina Scaffolds
- Authors
- Kim, Young-Hee; Anirban, Jyoti M.; Song, Ho-Yeon; Seo, Hyung-Seok; Lee, Byong-Taek
- Issue Date
- Feb-2011
- Publisher
- SAGE Publications
- Keywords
- tricalcium phosphate; biocompatibility; cytotoxicity; ECMs; micro-CT; alumina scaffold
- Citation
- Journal of Biomaterials Applications, v.25, no.6, pp 539 - 558
- Pages
- 20
- Journal Title
- Journal of Biomaterials Applications
- Volume
- 25
- Number
- 6
- Start Page
- 539
- End Page
- 558
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16746
- DOI
- 10.1177/0885328209356945
- ISSN
- 0885-3282
1530-8022
- Abstract
- Both tricalcium phosphate (TCP) and alumina have been extensively studied and shown to have high biocompatibility. Tricalcium phosphate has improved biodegradability and a higher solubility than hydroxyapatite. In contrast, alumina (Al2O3) is almost completely inert at physiological conditions and has been used as a biomaterial due to its wear resistance, high surface finish, and excellent hardness. Thus, the combination of these two implants would result in greater biocompatibility and phenotype maintenance. A polyurethane (PU) foam replica method was employed in this study to coat TCP on an alumina scaffold. The TCP-coated alumina scaffold was then sintered to generate a porous surface morphology. The pore sizes obtained using this approach ranged between 100-600 mu m, which is ideal for cellular proliferation. The cytotoxicity, cellular proliferation, differentiation, and ECM deposition on the coated scaffold resulted in longer-term viability of osteogenic markers compared to the non-coated scaffold. Moreover, the osteogenic properties of porous TCP-coated Al2O3 scaffolds were reported in this study using rabbit models. The TCP/Al2O3 scaffold and control Al2O3 scaffolds were implanted in the rabbit femur. The bone tissue response was analyzed with micro-computed tomography (micro CT) at 12 and 24 weeks after implantation. The porous scaffolds exhibited favorable hard and soft tissue responses at both time points. At 24 weeks, a three-fold increase in bone tissue ingrowth was observed in defects containing TCP-coated Al2O3 scaffolds compared to control Al2O3 scaffolds.
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Collections - College of Medicine > Department of Microbiology > 1. Journal Articles
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