Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patientsClinical significance of occult hepatitis B virus infection in chronic hepatitis C patients
- Other Titles
- Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients
- Authors
- 장재영; 정승원; 전성란; 이세환; 김상균; 천영국; 김영석; 조영덕; 김홍수; 진소영; 김연수; 김부성
- Issue Date
- 2011
- Publisher
- 대한간학회
- Keywords
- Occult infection; Hepatitis B virus; Hepatitis C virus; HBV DNA
- Citation
- Clinical and Molecular Hepatology, v.17, no.3, pp 206 - 212
- Pages
- 7
- Journal Title
- Clinical and Molecular Hepatology
- Volume
- 17
- Number
- 3
- Start Page
- 206
- End Page
- 212
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17106
- ISSN
- 2287-2728
2287-285X
- Abstract
- Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA.
In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17106)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.