Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga MiceEssential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice
- Other Titles
- Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice
- Authors
- 남궁우; Jae Kyu Noh; Su Kwan Kim; 이성진; 김경호; 오기봉; Jongheon Shin; 마응천
- Issue Date
- 2011
- Publisher
- 한국응용약물학회
- Keywords
- Thujopsis dolobrata; Atopic dermatitis; Beta-hexosaminidase; NC/Nga mouse; IgE
- Citation
- Biomolecules & Therapeutics, v.19, no.1, pp.102 - 108
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 19
- Number
- 1
- Start Page
- 102
- End Page
- 108
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17354
- ISSN
- 1976-9148
- Abstract
- We examined the effects of essential oil from Thujopsis dolobrata Sieb. et Zucc. var. hondai Makino (EOTD) (Cupressaceae) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Treatment with EOTD twice daily for two weeks ameliorate AD-like skin lesions induced by DNCB (2,4 dinitrochlorobenzene), and clinical scores were reduced to 7.29, 7.07, and 4.5 points in the groups treated with 1.5%, 3.0%, and 6.0% extract (p<0.01) respectively, from the 15.0 score obtained using vehicle. EOTD inhibited the infi ltration of mast cells into the AD-like skin lesion in NC/Nga mice (p<0.01) and also reduced serum histamine and IgE levels (p<0.05). Furthermore, it dose-dependently inhibited the release of beta-hexosaminidase from rat basophilic leukemia RBL 2H3cells. These results indicate that EOTD reduces AD-like skin lesions by inhibiting the production of IgE and histamine, and, thus,IgE-mediated degranulation.
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