Association Between Interleukin-3 Gene Polymorphism and Acute Rejection After Kidney Transplantation
- Authors
- Lee, D-Y.; Song, S-B.; Moon, J-Y.; Jeong, K-H.; Park, S. J.; Kim, H-J.; Kang, S. W.; Lee, S-H.; Kim, Y-H.; Chung, J-H.; Ihm, C-G.; Lee, T-W.
- Issue Date
- Dec-2010
- Publisher
- Appleton & Lange
- Citation
- Transplantation Proceedings, v.42, no.10, pp 4501 - 4504
- Pages
- 4
- Journal Title
- Transplantation Proceedings
- Volume
- 42
- Number
- 10
- Start Page
- 4501
- End Page
- 4504
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17470
- DOI
- 10.1016/j.transproceed.2010.09.153
- ISSN
- 0041-1345
1873-2623
- Abstract
- Backgrourd. Acute rejection (AR) after kidney transplantation resulting from alloimmune responses has a negative effect on graft survival. AR is mainly caused by T-cell immune responses activated by cytokines, including interleukin (IL)-2, -4, and -7. Many reports have shown that single nucleotide polymorphisms (SNPs) of these cytokines can affect the occurrence of AR. IL-3, which is secreted by activated T cells, can mediate AR. Our study sought to investigate the association between SNPs of the IL3 gene and the occurrence of an AR episode (ARE). Methods. We analyzed 3 SNPs of IL3 (rs181781, rs2073506, and rs40401) among 330 renal recipients, 60 of whom had developed an ARE. SNPs of the IL3 gene, including 1 exonic SNP (rs40401) and 2 regulatory thought to be promoter SNPs (rs181781 and rs2073506). Results. The genotypes of 60 ARE subjects and the 270 patients without AR demonstrated a significant relationship between genotype frequencies and the SNPs. The occurrence of an ARE was associated with rs181781 (P = .041, dominant model), rs2073506 (P = .009, codominant 1 model; P = .003, dominant model), and rs40401 (P = .014, recessive model). Among haplotypes, AAT showed a significant association with ARE. (P = .0033). Conclusion. Our results suggest that IL3 gene polymorphisms were associated with this event.
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Collections - College of Medicine > Department of Clinical Pharmacology > 1. Journal Articles
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