Parthenolide Suppresses the Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Induced by Toll-Like Receptor 2 and 4 AgonistsParthenolide Suppresses the Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Induced by Toll-Like Receptor 2 and 4 Agonists
- Other Titles
- Parthenolide Suppresses the Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Induced by Toll-Like Receptor 2 and 4 Agonists
- Authors
- 윤형선; 이아름; 박세정; 윤세미; 이미영; 손부순
- Issue Date
- 2010
- Publisher
- 대한의생명과학회
- Keywords
- Toll-like receptors; Parthenolide; NF-κB; COX-2; iNOS
- Citation
- 대한의생명과학회지, v.16, no.1, pp.39 - 45
- Journal Title
- 대한의생명과학회지
- Volume
- 16
- Number
- 1
- Start Page
- 39
- End Page
- 45
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18500
- Abstract
- Toll-like receptors (TLRs), which are pattern recognition receptors (PRRs), recognize pathogen-associated molecular patterns (PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-κB, leading to the induction of inflammatory gene products such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Parthenolide, a sesquiterpene lactone isolated from the herb feverfew (Tanacetum parthenium), has been used as folk remedies to treat many chronic diseases for many years. In the present report, we present biochemical evidence that parthenolide inhibits the NF-κB activation induced by TLR agonists and the overexpression of downstream signaling components of TLRs, MyD88, IKKβ, and p65. Parthenolide also inhibits TLR agonists-induced COX-2 and iNOS expression. These results suggest that parthenolide can modulate the immune responses regulated by TLR signaling pathways.
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- Appears in
Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
- College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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