The Effect of Low-dose Ketamine on Post-caesarean Delivery Analgesia after Spinal Anesthesia
- Authors
- Han, Seung Yeup; Jin, Hee Cheol; Yang, Woo Dae; Lee, Joon Ho; Cho, Seong Hwan; Chae, Won Seok; Lee, Jeong Seok; Kim, Yong Ik
- Issue Date
- Jul-2013
- Publisher
- 대한통증학회
- Keywords
- caesarean delivery; ketamine; patient-controlled analgesia; preemptive analgesia; spinal anesthesia
- Citation
- The Korean Journal of Pain, v.26, no.3, pp 270 - 276
- Pages
- 7
- Journal Title
- The Korean Journal of Pain
- Volume
- 26
- Number
- 3
- Start Page
- 270
- End Page
- 276
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18665
- DOI
- 10.3344/kjp.2013.26.3.270
- ISSN
- 2005-9159
2093-0569
- Abstract
- Background: Ketamine, an N-methyl-D-aspartate receptor antagonist, might play a role in postoperative analgesia, but its effect on postoperative pain after caesarean section varies with study design. We investigated whether the preemptive administration of low-dose intravenous ketamine decreases postoperative opioid requirement and postoperative pain in parturients receiving intravenous fentanyl with patient- controlled analgesia (PCA) following caesarean section. Methods: Spinal anesthesia was performed in 40 parturients scheduled for elective caesarean section. Patients in the ketamine group received a 0.5 mg/kg ketamine bolus intravenously followed by 0.25 mg/kg/h continuous infusion during the operation. The control group received the same volume of normal saline. Immediately after surgery, the patients were connected to a PCA device set to deliver 25-mu g fentanyl as an intravenous bolus with a 15-min lockout interval and no continuous dose. Postoperative pain was assessed using the cumulative dose of fentanyl and visual analog scale (VAS) scores at 2, 6, 24, and 48 h postoperatively. Results: Significantly less fentanyl was used in the ketamine group 2 h after surgery (P = 0.033), but the difference was not significant at 6, 12, and 24 h postoperatively. No significant differences were observed between the VAS scores of the two groups at 2, 6, 12, and 24 h postoperatively. Conclusions: Intraoperative low-dose ketamine did not have a preemptive analgesic effect and was not effective as an adjuvant to decrease opioid requirement or postoperative pain score in parturients receiving intravenous PCA with fentanyl after caesarean section.
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Collections - College of Medicine > Department of Anesthesiology > 1. Journal Articles
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