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Astragaloside IV Suppresses Hepatic Proliferation in Regenerating Rat Liver after 70% Partial Hepatectomy via Down-Regulation of Cell Cycle Pathway and DNA Replicationopen access

Authors
Lee, Gyeong-SeokJeong, Hee-YeonYang, Hyeon-GungSeo, Young-RanJung, Eui-GilLee, Yong-SeokNam, Kung-WooKim, Wan-Jong
Issue Date
May-2021
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
astragaloside IV; Astragalus membranaceus; huang qi; Astragali Radix; liver; liver regeneration; 70% partial hepatectomy; proliferation; rat
Citation
Molecules, v.26, no.10, pp 1 - 13
Pages
13
Journal Title
Molecules
Volume
26
Number
10
Start Page
1
End Page
13
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18876
DOI
10.3390/molecules26102895
ISSN
1420-3049
Abstract
Astragaloside IV (AS-IV) is one of the major bio-active ingredients of huang qi which is the dried root of Astragalus membranaceus (a traditional Chinese medicinal plant). The pharmacological effects of AS-IV, including anti-oxidative, anti-cancer, and anti-diabetic effects have been actively studied, however, the effects of AS-IV on liver regeneration have not yet been fully described. Thus, the aim of this study was to explore the effects of AS-IV on regenerating liver after 70% partial hepatectomy (PHx) in rats. Differentially expressed mRNAs, proliferative marker and growth factors were analyzed. AS-IV (10 mg/kg) was administrated orally 2 h before surgery. We found 20 core genes showed effects of AS-IV, many of which were involved with functions related to DNA replication during cell division. AS-IV down-regulates MAPK signaling, PI3/Akt signaling, and cell cycle pathway. Hepatocyte growth factor (HGF) and cyclin D1 expression were also decreased by AS-IV administration. Transforming growth factor beta 1 (TGF beta 1, growth regulation signal) was slightly increased. In short, AS-IV down-regulated proliferative signals and genes related to DNA replication. In conclusion, AS-IV showed anti-proliferative activity in regenerating liver tissue after 70% PHx.
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