Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse modelopen access
- Authors
- Yea, Ji-Hye; Yoon, Yeo Min; Lee, Jun Hee; Yun, Chul Won; Lee, Sang Hun
- Issue Date
- Nov-2021
- Publisher
- SAGE-Hindawi Access to Research
- Keywords
- Chronic kidney disease; mesenchymal stem cell; exosome; inflammation; fibrosis
- Citation
- Journal of Tissue Engineering, v.12, no.0, pp 1 - 13
- Pages
- 13
- Journal Title
- Journal of Tissue Engineering
- Volume
- 12
- Number
- 0
- Start Page
- 1
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20101
- DOI
- 10.1177/20417314211059624
- ISSN
- 2041-7314
- Abstract
- Chronic kidney disease (CKD) is defined as structural and functional abnormalities of the kidney due to inflammation and fibrosis. We investigated the therapeutic effects of exosomes secreted by melatonin-stimulated mesenchymal stem cells (Exocue) on the functional recovery of the kidney in a CKD mouse model. Exocue upregulated gene expression of micro RNAs (miRNAs) associated with anti-inflammatory and anti-fibrotic effects. Exocue-treated groups exhibited low tumor necrosis factor-alpha and transforming growth factor-beta levels in serum and fibrosis inhibition in kidney tissues mediated through regulation of cell apoptosis and proliferation of fibrosis-related cells. Exocue treatment decreased the gene expression of CKD progression-related miRNAs. Moreover, the CKD severity was alleviated in the Exocue group via upregulation of aquaporin 2 and 5 levels and reduction of blood urea nitrogen and creatinine, resulting in functional recovery of the kidney. In conclusion, Exocue could be a novel therapeutic agent for treating CKD by regulating inflammation and fibrosis.
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Collections - College of Medicine > Department of Biochemistry > 1. Journal Articles
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