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Sex, menopause, and age differences in the associations of persistent organic pollutants with thyroid hormones, thyroxine-binding globulin, and peripheral deiodinase activity: A cross-sectional study of the general Korean adult population

Authors
Kim, Min JooChoi, SohyeonKim, SunmiLee, InaeMoon, Min KyongChoi, KyunghoPark, JeongimCho, Yoon HeeKwon, Young MinYoo, JiyoungCheon, Gi JeongPark, Young Joo
Issue Date
Sep-2022
Publisher
Academic Press Inc.
Keywords
Iodothyronine deiodinase; Persistent organic pollutants; Polychlorinated biphenyls; Thyroid stimulating hormone (TSH); Thyroid hormones
Citation
Environmental Research, v.212, no.A, pp.1 - 10
Journal Title
Environmental Research
Volume
212
Number
A
Start Page
1
End Page
10
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20624
DOI
10.1016/j.envres.2022.113143
ISSN
0013-9351
Abstract
Persistent organic pollutants (POPs) can disrupt the thyroid hormone system in humans. We assessed the associations of several POPs with serum thyroid hormones (T3 and T4) and thyroid-stimulating hormone, and investigated the modulating effects of sex, menopausal status, and age on these associations, in a subgroup of the adult population (n = 1250) from the Korean National Environmental Health Survey. PCB105 and PCB118 were negatively associated with total T4 in premenopausal females and males aged < 50, whereas the associations were insignificant in other groups. PCB180, p,p'-DDE, and p,p'-DDT showed positive associations with total T3 in postmenopausal females; however, among males aged > 50, PCB118, PCB138, and p,p'-DDE showed negative associations with total T3. The effects of exposure to multiple POPs were examined in multi-factor analyses. Factor 2 comprised PCB52, hexachlorobenzene, and BDE-47 was associated with an increase in free T4 in premenopausal females (beta = 0.015, p = 0.024), while Factor 1, which contained most POPs, was associated with a change in total T3 in postmenopausal females (beta = 0.032, p = 0.040) and males aged >= 50 (beta =-0.039, p = 0.023). Changes in total T4 or total T3 could be explained by differences in thyroxine-binding globulin (TBG) and peripheral deiodinase activity (G(D)). Negative associations of TBG with PCB105 in premenopausal females and PCB153 in males aged < 50 may mediate the effect of decreasing total T4. PCB180, p,p'-DDE, p,p'-DDT, and Factor 1 were positively associated with G(D), which is consistent with an increased total T3 in postmenopausal females. PCB118 was negatively associated with G(D) and total T3 in males aged >= 50. BDE-47 and beta-hexa-chlorocyclohexane were associated with thyroid autoantibodies in premenopausal females and males aged < 50. Our observations suggest that the thyroid-disrupting effects of POPs may differ by sex, sex hormonal status, and age, and may be mediated by TBG and G(D).
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자연과학대학 (Department of Environmental Health Science)
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