Bone formation effect of highly concentrated tricalcium phosphate biocomposite screws in a rabbit osteoporosis model
- Authors
- Jeong, Je Hoon; Jin, Eun-Sun; Kim, Ji Yeon; Min, JoongKee; Jeon, Sang Ryong; Lee, Minsu; Choi, Kyoung Hyo
- Issue Date
- Jun-2022
- Publisher
- Elsevier BV
- Keywords
- animal model; biocomposite screw; implant; osteoporosis; tricalcium phosphate
- Citation
- Journal of Orthopaedic Research, v.40, no.6, pp 1321 - 1328
- Pages
- 8
- Journal Title
- Journal of Orthopaedic Research
- Volume
- 40
- Number
- 6
- Start Page
- 1321
- End Page
- 1328
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20778
- DOI
- 10.1002/jor.25171
- ISSN
- 0736-0266
1554-527X
- Abstract
- The purpose of this study was to determine the efficacy of highly concentrated tricalcium phosphate (TCP) biocomposite screws on local bone formation in a rabbit model of osteoporosis induced by bilateral ovariohysterectomy (OHE). Fourteen 24-week-old female New Zealand rabbits (weight, 3-3.5 kg) were divided into two groups: (1) OHE and biodegradable poly(lactic-co-glycolic acid) (PLGA) without ss-TCP plate or screw insertion (OHE/Bio ScRew [BSR]) group and (2) OHE and biocomposite PLGA with highly concentrated ss-TCP plate and screw insertion (OHE/highly concentrated ss-triCalcium phosphate [HCCP]). Both groups underwent bilateral OHE and had two different types of screws and plates inserted at the proximal tibia. Bilateral tibiae were extracted at 25 weeks post-OHE. The extracted tibiae were scanned with ex vivo microcomputed tomography (micro-CT). Parameters including bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb. Th), and trabecular separation (Tb. Sp) were evaluated after staining the tibial samples with hematoxylin and eosin (H&E) and Masson's trichrome. We then performed pathological assessments. Micro-CT images revealed improved new bone formation near the implant in the OHE/HCCP group with higher values of BMD, BV/TV, and Tb.N but lower values of Tb. Th and Tb. Sp than the OHE/BSR group. Analyses of H&E and Masson's trichrome staining showed better new bone formation around the implant in the OHE/HCCP group than in the OHE/BSR group. The use of highly concentrated TCP biocomposite screw and plate might improve local bone formation and facilitate osteoconductivity in an osteoporotic rabbit model.
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Collections - College of Medicine > Department of Neurosurgery > 1. Journal Articles
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