Fatigue is associated with depression independent of excessive daytime sleepiness in the general population
- Authors
- Sunwoo, Jun-Sang; Kim, Daeyoung; Chu, Min Kyung; Yun, Chang-Ho; Yang, Kwang Ik
- Issue Date
- Jun-2022
- Publisher
- Thieme Medical Publishers
- Keywords
- Fatigue; Sleepiness; Depression; Sleep duration
- Citation
- Sleep and Breathing, v.26, no.2, pp 933 - 940
- Pages
- 8
- Journal Title
- Sleep and Breathing
- Volume
- 26
- Number
- 2
- Start Page
- 933
- End Page
- 940
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20989
- DOI
- 10.1007/s11325-021-02448-3
- ISSN
- 1520-9512
1522-1709
- Abstract
- Purpose This study aimed to investigate sleep problems and comorbid conditions associated with fatigue in the general population. Methods The data were obtained from a nationwide cross-sectional survey conducted in 2018. The Fatigue Severity Scale was used to assess fatigue. We examined sleep habits, such as workday sleep duration, chronotype, and free-day catch-up sleep, excessive daytime sleepiness (EDS), depression, and other comorbid conditions. We conducted multiple logistic regression analysis with the presence of fatigue as a dependent variable. Results Of 2,493 adults aged 19 to 92 years, 50% men, mean age was 47.9 +/- 16.4 years. The average workday sleep duration was 7.1 +/- 1.1 h, and the prevalence of fatigue was 31%. After adjusting for potential confounders, fatigue was associated with EDS (odds ratio [OR] 3.751, 95% confidence interval [CI] 2.928-4.805), depression (OR 3.736, 95% CI 2.701-5.169), perceived insufficient sleep (OR 1.516, 95% CI 1.249-1.839), free-day catch-up sleep (OR 1.123, 95% CI 1.020-1.235), less alcohol intake (OR 0.570, 95% CI 0.432-0.752), and physical inactivity (OR 0.737, 95% CI 0.573-0.948). On subgroup analysis, fatigue was additionally associated with short workday sleep duration (OR 0.899, 95% CI 0.810-0.997) in individuals without EDS. However, among those with EDS, only depression (OR 2.842, 95% CI 1.511-5.343) and less alcohol intake (OR 0.476, 95% CI 0.247-0.915) were associated with fatigue. Conclusion Fatigue was significantly associated with depression independent of EDS. Further research is warranted to better understand the pathophysiological relationship between fatigue, depression, and sleep.
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Collections - College of Medicine > Department of Neurology > 1. Journal Articles
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