Exosomal miRNA Profile in Small-for-Gestational-Age Children: A Potential Biomarker for Catch-Up Growthopen access
- Authors
- Jeong, Hwal Rim; Han, Jae-A; Kim, Heeji; Lee, Hye Jin; Shim, Young Suk; Kang, Min Jae; Yoon, Jong Seo; Ryu, Seongho; Hwang, Il Tae
- Issue Date
- Jun-2022
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- SGA; catch-up growth; miRNA; exosome
- Citation
- Genes, v.13, no.6, pp 1 - 15
- Pages
- 15
- Journal Title
- Genes
- Volume
- 13
- Number
- 6
- Start Page
- 1
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21130
- DOI
- 10.3390/genes13060938
- ISSN
- 2073-4425
- Abstract
- Objective: The mechanism underlying postnatal growth failure and catch-up growth in small-for-gestational-age (SGA) children is poorly understood. This study investigated the exosomal miRNA signature associated with catch-up growth in SGA children. Methods: In total, 16 SGA and 10 appropriate-for-gestational-age (AGA) children were included. Serum exosomal miRNA was analyzed using next-generation sequencing (NGS). Exosomal miRNA was profiled for five SGA children with catch-up growth (SGA-CU), six SGA children without CU growth (SGA-nCU), and five AGA children. Results: Exosomal miRNA profiles were clustered into three clear groups. The exosomal miRNA expression profiles of the SGA-nCU group differed from those of the SGA-CU and AGA groups. In all, 22 miRNAs were differentially expressed between SGA-nCU and AGA, 19 between SGA-nCU and SGA-CU, and only 6 between SGA-CU and AGA. In both SGA-nCU and SGA-CU, miR-874-3p was upregulated and miR-6126 was downregulated. Therefore, these two miRNAs could serve as biomarkers for SGA. Compared with SGA-CU and AGA, miR-30c-5p, miR-363-3p, miR-29a-3p, and miR-29c-3p were upregulated in SGA-nCU, while miR-629-5p and miR-23a-5p were downregulated. These six miRNAs could be associated with growth failure in SGA-nCU children. Conclusions: SGA children without CU have a distinct exosomal miRNA expression profile compared with AGA and SGA children with CU. Exosomal miRNAs could serve as novel biomarkers for CU.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Pediatrics > 1. Journal Articles
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