Shared genetic architectures of subjective well-being in East Asian and European ancestry populations
- Authors
- Kim, Soyeon; Kim, Kiwon; Hwang, Mi Yeong; Ko, Hyunwoong; Jung, Sang-Hyuk; Shim, Injeong; Cha, Soojin; Lee, Hyewon; Kim, Beomsu; Yoon, Joohyun; Ha, Tae Hyon; Kim, Doh Kwan; Kim, Jinho; Park, Woong-Yang; Okbay, Aysu; Kim, Bong-Jo; Kim, Young Jin; Myung, Woojae; Won, Hong-Hee
- Issue Date
- Jul-2022
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- Nature Human Behaviour, v.6, no.7, pp 1014 - 1026
- Pages
- 13
- Journal Title
- Nature Human Behaviour
- Volume
- 6
- Number
- 7
- Start Page
- 1014
- End Page
- 1026
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21269
- DOI
- 10.1038/s41562-022-01343-5
- ISSN
- 2397-3374
- Abstract
- Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health. Won et al. compare genetic associations with subjective well-being in Korean and European populations, and show significant cross-population genetic correlations
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medical Sciences > Department of Health Administration and Management > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.