Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Outcome of pallidal deep brain stimulation for treating isolated orofacial dystonia

Authors
Huh, RyoongChung, MoonyoungJang, Il
Issue Date
Sep-2022
Publisher
Springer Verlag
Keywords
Blepharospasm; Meige syndrome; Orofacial dystonia; Oromandibular dystonia; Deep brain stimulation
Citation
Acta Neurochirurgica, v.164, no.9, pp 2287 - 2298
Pages
12
Journal Title
Acta Neurochirurgica
Volume
164
Number
9
Start Page
2287
End Page
2298
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21360
DOI
10.1007/s00701-022-05320-9
ISSN
0001-6268
0942-0940
Abstract
Background Isolated orofacial dystonia is a rare segmental neurological disorder that affects the eye, mouth, face, and jaws. Current literature on pallidal surgery for orofacial dystonia is limited to case reports and small-scale studies. This study was to investigate clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with isolated orofacial dystonia. Methods Thirty-six patients who underwent GPi DBS at Incheon St. Mary's Hospital, The Catholic University of Korea, between 2014 and 2019 were included in this study. Burke-Fahn-Marsden Dystonia Rating Scale, Unified Dystonia Rating Scale, and Global Dystonia Severity Rating Scale were retrospectively retrieved for analysis before surgery, at 6-month follow-up as short-term outcome, and at follow-up over 1 year (12 months to 69 months) as long-term results. Results Mean total BFMDRS-M scores at the three time points (baseline, 6 months, and over 1 year follow-up) were 11.6 +/- 4.9, 6.1 +/- 5.2 (50.3 +/- 29.9% improvement, p < 0.05), and 4.3 +/- 4.2 (65.0 +/- 24.2% improvement, p < 0.05), respectively. In terms of UDRS and GDS, improvement rates were 45.1% (p < 0.001) and 47.7% (p < 0.001) at 6 months, and 63.8% (p < 0.001) and 65.7% (p < 0.001) at over 1 year after surgery, respectively. Conclusions Bilateral GPi DBS in isolated orofacial dystonia can be effective if conservative treatment option fails. Its benefit is not only observed in a short term, but also maintained in a long-term follow-up.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Neurosurgery > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Chung, Moon young photo

Chung, Moon young
College of Medicine (Department of Neurosurgery)
Read more

Altmetrics

Total Views & Downloads

BROWSE