A split-face study to evaluate the efficacy of a dissolving microneedle-encapsulated niacinamide skin patch for the reduction of facial hyperpigmentationopen accessA split-face study to evaluate the efficacy of a dissolving microneedle-encapsulated niacinamide skin patch for the reduction of facial hyperpigmentation
- Other Titles
- A split-face study to evaluate the efficacy of a dissolving microneedle-encapsulated niacinamide skin patch for the reduction of facial hyperpigmentation
- Authors
- 배준석; 남승민; 차한규; 박은수
- Issue Date
- Oct-2022
- Publisher
- 대한미용성형외과학회
- Keywords
- Hyperpigmentation / Vitamin B3 / Skin
- Citation
- Archives of Aesthetic Plastic Surgery, v.28, no.4, pp.113 - 118
- Journal Title
- Archives of Aesthetic Plastic Surgery
- Volume
- 28
- Number
- 4
- Start Page
- 113
- End Page
- 118
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21586
- ISSN
- 2234-0831
- Abstract
- ackground This study aimed to evaluate the efficacy and safety of a dissolving mi croneedle (DMN)-encapsulated niacinamide skin patch to reduce facial hyperpigmen tation.
Methods A split-face study was conducted between April and June 2022 in 17 patients treated with a DMN-encapsulated niacinamide skin patch, which was applied only on the right side of the face, while the left face remained free of a pigmentation-improv ing agent. A topical moisturizer and physical sunscreen were applied on both sides of the face for 2 weeks. We compared both sides of the face 2 weeks after applying the skin patch using an automatic skin analysis device to investigate skin pigmentation. The melasma severity scores of both sides were evaluated before and 2 weeks after appli cation.
Results A significant difference in the epidermal pigmentation score between pre treatment and 2 weeks after treatment was noted on the right side (P<0.05), but not on the left side of the face (P>0.05). A significant difference in the melanin score be tween pre-treatment and 2 weeks after treatment was noted on the right side (P<0.05), but not on the left side (P>0.05) of the face. There was no significant differ ence in the melasma severity score on either side of the face between pre-treatment and 2 weeks after treatment (P>0.05).
Conclusions The application of a DMN-encapsulated niacinamide skin patch to improve skin pigmentation may yield good outcomes and provide comfort to patients without any complications.
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Collections - College of Medicine > Department of Plastic Surgery > 1. Journal Articles
- College of Medicine > Department of Neurology > 1. Journal Articles
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