Diagnostic performance of the six-item cognitive impairment test as first-step screening for dementia: a meta-analysis
- Authors
- Park, Seong-Hi
- Issue Date
- Sep-2022
- Publisher
- Australian Academic Press Pty Ltd.
- Keywords
- Dementia; cognitive dysfunction; neuropsychological tests; sensitivity and specificity; meta-analysis
- Citation
- Brain Impairment, v.24, no.2, pp 412 - 423
- Pages
- 12
- Journal Title
- Brain Impairment
- Volume
- 24
- Number
- 2
- Start Page
- 412
- End Page
- 423
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21642
- DOI
- 10.1017/BrImp.2022.22
- ISSN
- 1443-9646
1839-5252
- Abstract
- Objective: Dementia, a slowly progressive disease, is poorly diagnosed. One reason is that it is difficult to use the screening tools. The six-item cognitive impairment test (6-CIT) is brief, with six items, and has a confirmed scoring system that can easily be used by an average individual. This review aimed to analyze the predictive validity of the 6-CIT including comparisons with other tools such as the Mini-Mental State Examination (MMSE). Methods: Literature searches were performed on the MEDLINE, EMBASE, CINAHL, and PsycArticles using the dementia and 6-CITas keywords. The Quality Assessment of Diagnostic Accuracy Studies-2 was applied to assess the risk of bias. Results: Seven studies with 6,831 participants that met the selection criteria were included. The pooled sensitivity of the 6-CIT analyzed in seven studies was 0.82 (95% CI 0.73-0.89), the pooled specificity was 0.87, and the summary receiver operating characteristic (sROC) curve was 0.90 (SE = 0.04). The diagnostic performance of the 6-CIT and MMSE was compared in three studies. The pooled sensitivity of the 6-CIT was 0.85, the pooled specificity was 0.91, and the sROC curve was 0.91, whereas the MMSE values were 0.70, 0.93, and 0.68, respectively. Conclusion: This review presents evidence that the 6-CIT has excellent dementia screening performance and could be used as a potential alternative to the MMSE. The 6-CIT may provide an opportunity for early detection of dementia.
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