Value of C-11 methionine PET/CT in patients with intracranial germinomaopen access
- Authors
- Park, Yong-Jin; Lee, Ji Won; Cho, Hee Won; Choe, Yearn Seong; Lee, Kyung-Han; Choi, Joon Young; Sung, Ki Woong; Moon, Seung Hwan
- Issue Date
- Feb-2022
- Publisher
- Public Library of Science
- Citation
- PLoS ONE, v.17, no.2
- Journal Title
- PLoS ONE
- Volume
- 17
- Number
- 2
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21713
- DOI
- 10.1371/journal.pone.0263690
- ISSN
- 1932-6203
- Abstract
- Purpose The purpose of this study was to investigate the value of C-11 methionine (MET) positron emission tomography (PET)/computed tomography (CT) in patients with intracranial germinoma (IG). Material and methods We conducted a retrospective analysis of 21 consecutive patients with pathologically confirmed IGs and eight patients with intracranial non-germinomas (INGs) located in a similar region. Clinical characteristics, imaging findings, and tumor markers such as alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) were used as clinical variables. Maximum standardized uptake value (SUVmax), tumor-to-normal tissue (T/N) ratio, and visual scoring of tumor were used as MET PET parameters. Results All IGs were well visualized on MET PET with a three-grade visual scoring system. In addition, SUVmax of IGs was higher than that of INGs (P = 0.005). Pre-treatment (Pre-Tx) T/N ratio was significantly correlated with pre-Tx serum HCG (P = 0.031). Moreover, MET PET parameters showed significant associations with tumor location, sex, KRAS variant, and symptoms. Conclusion MET PET/CT could be a useful diagnostic tool in patients suspected of having IGs. In addition, the MET avidity of tumor is a potential surrogate biomarker of HCG, which has been used as a diagnostic marker for IGs. Tumor MET parameters also had significant differences according to tumor locations, sex, symptoms, and KRAS mutation. However, MET avidity of tumors had no significant prognostic value.
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Collections - College of Medicine > Department of Otorhinolaryngology > 1. Journal Articles
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