Gadoxetate disodium-enhanced MRI for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: late portal venous phase may improve identification of enhancing capsule
- Authors
- Kim, Hyeji; Kim, Seung Soo; Shin, Hyeong Cheol; Choi, Seo-Youn; Lee, Ji Eun; Lee, Woong Hee; Park, Chan Ho; Lee, Hyoung Nam; Kim, Shin Young; 박혜림; Heo, Nam Hun
- Issue Date
- Feb-2023
- Publisher
- Springer New York
- Keywords
- Hepatocellular carcinoma; Liver neoplasm; Magnetic resonance imaging; Gadoxetate disodium
- Citation
- Abdominal Radiology
- Journal Title
- Abdominal Radiology
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21956
- DOI
- 10.1007/s00261-022-03756-2
- ISSN
- 2366-004X
2366-0058
- Abstract
- Purpose To investigate added value of late portal venous phase (LPVP) for identification of enhancing capsule (EC) on gadoxetate disodium-enhanced MRI (GD-MRI) for diagnosing hepatocellular carcinoma (HCC) in patients with chronic liver disease (CLD). Methods This retrospective study comprised 116 high-risk patients with 128 pathologically proven HCCs who underwent GD-MRI including arterial phase, conventional portal venous phase (CPVP, 60 s), LPVP (mean, 104.4 +/- 6.7 s; range, 90-119 s), and transitional phase (TP, 3 min). Two independent radiologists assessed the presence of major HCC features, including EC on CPVP and/or TP (CPVP/TP) and EC on LPVP. The frequency of EC was compared on GD-MRI between with and without inclusion of LPVP. The radiologists assigned Liver Imaging Reporting and Data System (LI-RADS) v2018 categories before and after identifying EC on LPVP. Results Of the total 128 HCCs, 74 and 73 revealed EC on CPVP/TP for reviewer 1 and 2, respectively. After inclusion of LPVP, each reviewer identified seven more EC [Reviewer 1, 57.8% (74/128) vs. 63.3% (81/128); Reviewer 2, 57.0% (73/128) vs. 62.5% (80/128); P = 0.016, respectively]. Sensitivities of LR-5 assignment for diagnosing HCCs were not significantly different in GD-MRI with or without LPVP for EC identification [Reviewer 1, 71.9% (92/128) vs. 72.7% (93/128); Reviewer 2, 75.0% (96/128) vs. 75.8% (97/128); P= 1.000, respectively]. Conclusion Including the LPVP in GD-MRI may improve identification of EC of HCC in patients with CLD. However, LI-RADS v2018 using GD-MRI showed comparable sensitivity for diagnosing HCC regardless of applying LPVP for EC.
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