Development of nanoclay-based nanocomposite surfaces with antibacterial properties for potential biomedical applications
- Authors
- Levana, Odelia; Jeong, Ji Hoon; Hur, Sung Sik; Seo, Wonbin; Lee, Minho; Noh, Kyung Mu; Hong, Soonkook; Park, Jae Hong; Lee, Ju Hun; Choi, Chulmin; Hwang, Yongsung
- Issue Date
- Apr-2023
- Publisher
- 한국공업화학회
- Keywords
- Antibacterial surface; Montmorillonite; Bentonite; Quaternary ammonium salts
- Citation
- Journal of Industrial and Engineering Chemistry, v.120, pp 448 - 459
- Pages
- 12
- Journal Title
- Journal of Industrial and Engineering Chemistry
- Volume
- 120
- Start Page
- 448
- End Page
- 459
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22387
- DOI
- 10.1016/j.jiec.2022.12.052
- ISSN
- 1226-086X
1876-794X
- Abstract
- Biofilm formation on biomedical implant surfaces requires bacterial adhesion, which increases the risk of infection and chronic inflammation. Since intercalation of quaternary ammonium salts (QAS) into mont-morillonite (MMT) clay, known as organoclays, has been reported to increase surface broad-spectrum antibacterial properties, we aimed to develop an antibacterial surface composed of thermoplastic poly-urethane (TPU) embedded with bentonite and MMT clay containing QAS to prevent initial bacterial attachment. We evaluated its potential application in reducing bacterial adhesion and enhancing bacteria-killing properties using Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Our results demonstrated that the nanoclay-embedded TPU surfaces with QAS significantly reduced the adhesion of E. coli and S. aureus by 68.82% and 65.18%, respectively, compared to the plain TPU surfaces. Additionally, a higher nanoclay concentration coating on the surface could enhance its effectiveness, as shown by 85.34% and 82.74% reduction in E. coli and S. aureus adhesion and killing efficiency. Furthermore, we observed that nanoclay-embedded TPU surfaces had no detrimental effects on the via-bility of human dermal fibroblasts. Taken together, these techniques could provide novel strategies for inhibiting bacterial adhesion and supporting bacteria killing on biomedical implant surfaces, as the inves-tigated surfaces are simple to synthesize, efficient, and cost-effective. (c) 2023 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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- Appears in
Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
- College of Medicine > Department of Otorhinolaryngology > 1. Journal Articles
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