The adverse effects of selenomethionine on skeletal muscle, liver, and brain in the steelhead trout (Oncorhynchus mykiss)
- Authors
- Lee, Jang-Won; Deng, Dong-Fang; Lee, Jinsu; Kim, Kiyoung; Jung, Hyun Jin; Choe, Youngshik; Park, Seung Hwa; Yoon, Minjung
- Issue Date
- Nov-2020
- Publisher
- Elsevier BV
- Keywords
- Selenium neurotoxicity; Steelhead trout; Neuromuscular system; Histopathology; Oxidative stress
- Citation
- Environmental Toxicology and Pharmacology, v.80
- Journal Title
- Environmental Toxicology and Pharmacology
- Volume
- 80
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2354
- DOI
- 10.1016/j.etap.2020.103451
- ISSN
- 1382-6689
1872-7077
- Abstract
- Juvenile Oncorhynchus mykiss (average weight 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was elevated compared to the controls. In the brain, the dopamine levels at 61.58 mg Se/kg diet and the serotonin levels over 15.37 mg Se/kg diets were significantly increased, whereas the 3,4-dihydroxyphenylacetic acid, homovanillic acid, and dopamine turnover, and the 5-hydroxyindoleacetic acid and serotonin turnover over 30.79 mg Se/kg diets were decreased. In muscle, the 3-nitrotyrosine level over 15.37 mg Se/kg diets, acetylcholine esterase activity over 30.79 mg Se/kg diets, and histological alterations over 8.79 mg Se/kg diets were increased. Our current results showed that selenomethionine disrupted dopamine and serotonin metabolism in the brain and damaged the neuromuscular system in skeletal muscle.
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Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
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