Clinical value of dual-phase F-18 sodium fluoride PET/CT for diagnosing bone metastasis in cancer patients with solitary bone lesion
- Authors
- Lee, Jeong Won; Park, Yong-Jin; Jeon, Youn Soo; Kim, Ki Hong; Lee, Jong Eun; Hong, Sung Hoon; Lee, Sang Mi; Jang, Su Jin
- Issue Date
- Nov-2020
- Publisher
- ROOM 604 6-F HOLLYWOOD CENTER, 77-91, QUEENS ROAD, SHEUNG WAN, PEOPLES R CHINA, HONG KONG, 00000
- Keywords
- Bone; diagnosis; F-18 Sodium-fluoride (NaF); metastasis; positron emission tomography (PET)
- Citation
- QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, v.10, no.11, pp 2098 - 2111
- Pages
- 14
- Journal Title
- QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
- Volume
- 10
- Number
- 11
- Start Page
- 2098
- End Page
- 2111
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2375
- DOI
- 10.21037/qims-20-607
- ISSN
- 2223-4292
2223-4306
- Abstract
- Background: The present study aimed to investigate whether dual-phase F-18 sodium-fluoride (NaF) positron emission tomography/computed tomography (PET/CT) could improve the diagnostic accuracy of detecting bone metastasis in cancer patients with a solitary bone lesion compared to conventional F-18 NaF PET/CT. Methods: We retrospectively enrolled 113 cancer patients who underwent dual-phase F-18 NaF PET/CT for the differential diagnosis of a solitary bone lesion seen on bone scintigraphy. According to the dual phase PET/CT protocol, an early-phase scan was acquired immediately after radiotracer injection and a conventional F-18 NaF PET/CT scan was performed. The diagnostic abilities of the visual analysis of conventional and dual-phase PET/CT scans and two quantitative parameters (lesion-to-blood pool uptake ratio on early-phase scan and lesion-to-bone uptake ratio on conventional scan) for detecting bone metastasis were compared. The final diagnosis of bone metastasis was made by histopathological confirmation or follow-up imaging studies. Results: A metastatic bone lesion was diagnosed in 28 patients (24.8%). The sensitivity, specificity, and accuracy were 100.0%, 70.6%, and 77.9%, respectively, for visual analysis of conventional F-18 NaF PET/CT, 92.9%, 42.4%, 54.9%, respectively, for lesion-to-bone uptake ratio, 96.4%, 88.2%, and 90.3%, respectively, for visual analysis of dual-phase PET/CT, and 92.9%, 81.2%, and 83.2%, respectively, for lesion-to-blood pool uptake ratio. Visual analysis of dual-phase PET/CT was shown to have the highest area under the receiver operating characteristic curve value (0.923; 95% CI, 0.858-0.965) among all parameters. Conclusions: Dual-phase F-18 NaF PET/CT showed a high diagnostic ability for detecting bone metastasis with improved specificity and accuracy compared to conventional F-18 NaF PET/CT in cancer patients. Dual-phase F-18 NaF PET/CT might help diagnose bone metastasis in patients with malignancies who were shown to have a solitary bone lesion on bone scintigraphy.
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Collections - College of Medicine > Department of Radiology > 1. Journal Articles
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