In vitro and in vivo evaluation of Ca/P-hyaluronic acid/gelatin based novel dental plugs for one-step socket preservationopen access
- Authors
- Kang, Hoe-Jin; Park, Seong-Su; Saleh, Tarek; Ahn, Kang-Min; Lee, Byong-Taek
- Issue Date
- Sep-2020
- Publisher
- Elsevier BV
- Keywords
- Dental bone substitute; Socket preservation; Bone regeneration; Hemostat; Calcium phosphate; Hyaluronic acid-gelatin
- Citation
- Materials & Design, v.194
- Journal Title
- Materials & Design
- Volume
- 194
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2515
- DOI
- 10.1016/j.matdes.2020.108891
- ISSN
- 0264-1275
1873-4197
- Abstract
- Teeth extraction is inevitable in the case of progressive or alveolar bone destructing chronic periodontitis. Unfortunately, the resulting bone defects may lead to many side effects. Here, we developed a novel dental-bone substitute to preserve the extraction socket for hemostasis and bone regeneration. Hyaluronic acid-gelatin hydrogel (HG) polymers, beta-tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP) ceramics were fabricated using freeze-drying methods. The HG/TCP/BCP plug was prepared to be easily applied by pouring the mixture of HG and TCP into the shell-shaped mold, followed by placing the sponge type of BCP in the core portion of the mold compared to HG/TCP and collagen plugs. In vitro studies showed that HG/TCP and HG/TCP/BCP plugs were cytocompatible and could promote osteogenesis by upregulating the expressions of bone-related genes COL1, RUNX2, ALP, and OPN. The rabbit-femur defect model revealed that the implanted HG/TCP/BCP plug, which showed excellent hemostatic property, promote bone regeneration with a high rate of collagen distribution along with ALP and OPN expressions more than could the HG/TCP plug at 3 months after implantation, whereas the collagen plugs just filled with chondrocytes for cartilages formation. The HG/TCP/BCP plug should be considered for potential dental applications for one-step socket preservation. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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Collections - College of Medicine > Department of Regenerative Medicine > 1. Journal Articles
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