The significance of programed cell death-ligand 1 expression in vestibular schwannomaopen access
- Authors
- Lee, Se A.; Chin, Susie; Jung, Shin; Lee, Kyung-Hwa; Moon, Kyung-Sub; Lee, Jong Dae
- Issue Date
- Sep-2023
- Publisher
- John Wiley and Sons Inc.
- Keywords
- immunochemistry; lymphocytes; neuroma acoustic; tumor-infiltrating
- Citation
- Brain and Behavior, v.13, no.9
- Journal Title
- Brain and Behavior
- Volume
- 13
- Number
- 9
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25325
- DOI
- 10.1002/brb3.3137
- ISSN
- 2162-3279
2162-3279
- Abstract
- BackgroundThe association between programed cell death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in vestibular schwannoma (VS) has been investigated in a few studies. These published studies report a difference in the PD-L1 positivity rate in malignant peripheral nerve sheath tumors. We examined PD-L1 expression and lymphocyte infiltration in patients with VS who had undergone surgical resection and investigated the association between PD-L1 expression and clinicopathological features. MethodsThe expression of PD-L1, CD8, and Ki-67 in 40 VS tissue specimens was investigated using immunohistochemistry, and a clinical review of the patients was performed. ResultsOf the 40 VS samples, 23 (57.5%) were positive for PD-L1 and 22 (55%) were positive for CD8. No significant differences in age, tumor size, pure-tone audiometry, speech discrimination, or Ki-67 expression were observed between patients in the PD-L1-positive and PD-L1-negative groups. A higher level of CD8-positive cell infiltration was observed in PD-L1-positive tumors than in PD-L1-negative tumors. ConclusionWe demonstrated that PD-L1 was expressed in VS tissues. Although no correlation was identified between clinical characteristics and PD-L1 expression, the association between PD-L1 and CD8 was confirmed. Thus, additional research on targeting PD-L1 is necessary to improve immunotherapy for VS in the future.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Otorhinolaryngology > 1. Journal Articles
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