Radio-protective effects of Thymus quinquecostatus Celak extract in mice
- Authors
- Han, Eui Jeong; Im, Seung Tae; Ahn, Ginnae; Lee, Seung-Hong
- Issue Date
- Sep-2023
- Publisher
- Pergamon Press Ltd.
- Keywords
- Thymus quinquecostatus; Water extract; Gamma ray; Radio -protective effect
- Citation
- Applied Radiation and Isotopes, v.199
- Journal Title
- Applied Radiation and Isotopes
- Volume
- 199
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25333
- DOI
- 10.1016/j.apradiso.2023.110881
- ISSN
- 0969-8043
1872-9800
- Abstract
- Thymus quinquecostatus Celak (TQC) is an aromatic herb, that possesses a wide range of biological properties. In the present study, we investigated the radio-protective effect of TQC water extract (TQCW) in gamma ray -exposed splenocytes, a peripheral immune cell and mice. Our results showed that the treatment with TQCW dose-dependently increased the viability of splenocytes. TQCW significantly increased the proliferation of splenocytes by reducing the production of intracellular reactive oxygen species (ROS) in 2 Gy-exposed spleno-cytes. Moreover, TQCW enhanced the hemopoietic system as increasing the number of endogenous spleen colony-forming units, and the number and the proliferation of splenocytes in 7 Gy-exposed mice. These results suggest that TQCW protects mice by enhancing the splenocytes proliferation and hemopoietic systems following exposure to gamma rays.
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Collections - College of Medical Sciences > Department of Pharmaceutical Engineering > 1. Journal Articles
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