L-carnitine이 3T3-L1 지방세포 분화에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이경애 | - |
dc.contributor.author | 조선기 | - |
dc.contributor.author | 김성호 | - |
dc.contributor.author | 이윤진 | - |
dc.date.accessioned | 2023-12-14T07:00:54Z | - |
dc.date.available | 2023-12-14T07:00:54Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 2287-1780 | - |
dc.identifier.issn | 2287-1772 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25713 | - |
dc.description.abstract | Purpose: This study investigates the effect of L-carnitine on 3T3-L1 cell adipocyte differentiation. Methods: The cytotoxicity of L-carnitine to 3T3-L1 was confirmed through the MTT assay, and fat accumulation of 3T3-L1 cells was observed by Oil-Red O staining. The effect of L-carnitine on adipogenesis-related protein expressions was determined with Western blot. Results: Compared to the control group, the degree of adipogenesis inhibition was confirmed by Oil-Red O staining. Intracellular liposynthesis-induced fat cell differentiation with MDI(1 μM dexamethasone, 1 μg/mL inulin, 0.5 mM 3-isobutyl-1-methylxanthine) showed inhibition rates of 86.0%, 52.3%, and 32.5% at L-carnitine concentrations of 1.25, 2.5, and 5 nM, respectively. Protein expression levels of PPARγ and C/EBPα, which are transcription factors expressed during adipocyte differentiation, decreased in a concentration-dependent manner after exposure to L-carnitine. Moreover, compared to the MDI alone treatment group, we confirmed that the expression of the fatty acid synthase regulator (FAS) decreased to 84.4%, 50.9%, and 9.3% in the L-carnitine 1.25, 2.5, and 5 nM treatment groups, respectively. Conclusion: These results indicate that L-carnitine has the potential to suppress fat accumulation and exert an anti-obesity effect. | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국식품조리과학회 | - |
dc.title | L-carnitine이 3T3-L1 지방세포 분화에 미치는 영향 | - |
dc.title.alternative | Effect of L-carnitine on 3T3-L1 adipocyte differentiation | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 한국식품조리과학회지, v.39, no.3, pp 227 - 233 | - |
dc.citation.title | 한국식품조리과학회지 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 227 | - |
dc.citation.endPage | 233 | - |
dc.identifier.kciid | ART002977003 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Key words: L-carnitine | - |
dc.subject.keywordAuthor | 3T3-L1 | - |
dc.subject.keywordAuthor | adipocyte | - |
dc.subject.keywordAuthor | differentiation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.