Anti-biofilm and anti-virulence effects of zerumbone against Acinetobacter baumannii
- Authors
- Kim, Hye-Rim; Shin, Seul; Jang, Hye-In; Eom, Yong-Bin
- Issue Date
- Aug-2020
- Publisher
- Society for General Microbiology
- Keywords
- Acinetobacter baumannii; anti-biofilm; anti-virulence; biofilm-associated protein (Bap); resistance-nodulation-division (RND)-type efflux pump; zerumbone
- Citation
- Microbiology, v.166, no.8, pp 717 - 726
- Pages
- 10
- Journal Title
- Microbiology
- Volume
- 166
- Number
- 8
- Start Page
- 717
- End Page
- 726
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2591
- DOI
- 10.1099/mic.0.000930
- ISSN
- 1350-0872
1465-2080
- Abstract
- Acinetobacter baumannii is a multidrug-resistant opportunistic pathogen that affects patients with a compromised immune system and is becoming increasingly important as a hospital-derived infection. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of zerumbone as a novel anti-biofilm and/or anti-virulence agent against A. baumannii. The results showed that zerumbone at sub-inhibitory doses decreased biofilm formation and disrupted established A. baumannii biofilms. The zerumbone-induced decrease in biofilm formation was dose-dependent based on the results of microtitre plate biofilm assays and confocal laser scanning microscopy. In addition, our data validated the anti-virulence efficacy of zerumbone, wherein it significantly interfered with the motility of A. baumannii. To support these phenotypic results, transcriptional analysis revealed that zerumbone downregulated the expression of biofilm- and virulence-associated genes (adeA, adeB, adeC and bap) in A. baumannii. Overall, our findings suggested that zerumbone might be a promising bioactive agent for the treatment of biofilm- and virulence-related infections caused by multidrug-resistant A. baumannii.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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