Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics: A Retrospective Chart Reviewopen access
- Authors
- Hong, Eun Ji; Yoon, Hee Jung; Kwon, Min Jung; Kim, Jae Yun; Kim, Jung Eun; Park, Young Lip; Lee, Sanghoon; Bae, Youin; Lee, Sul Hee
- Issue Date
- Apr-2024
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Keywords
- Biologics; Psoriasis; Risk factors
- Citation
- ANNALS OF DERMATOLOGY, v.36, no.2, pp 91 - 98
- Pages
- 8
- Journal Title
- ANNALS OF DERMATOLOGY
- Volume
- 36
- Number
- 2
- Start Page
- 91
- End Page
- 98
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26227
- DOI
- 10.5021/ad.23.074
- ISSN
- 1013-9087
2005-3894
- Abstract
- Background: Biologics have demonstrated high efficacy in achieving 'almost complete' skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving 'complete' skin clearance remains a treatment goal for some highly biologics -resistant patients, as residual lesions impact their quality of life. Objective: The risk factors for failure to achieve a Psoriasis Area and Severity Index (PASI) 100 response in patients with good response to biologics remain unknown. Methods: This retrospective study evaluated the risk factors by comparing patients who achieved complete skin clearance (PASI100) with those who achieved almost complete skin clearance (PASI90). A database of 131 psoriasis patients treated with biologics, who achieved a PASI90 or PASI100 response, was reviewed from a tertiary referral hospital in South Korea. The patients were classified into PASI90 and PASI100 groups according to their PASI response. Results: The PASI100 group had a lower prevalence of smoking history (adjusted odds ratio [OR], 0.34; 95% confidence interval [CI], 0.14-0.85; p=0.021) and psoriasis on the anterior lower legs at baseline (adjusted OR, 0.18; 95% CI, 0.03-0.99; p=0.049) than patients in the PASI90 group. Conclusion: This study suggested that smoking history and psoriatic skin lesions on the anterior lower legs are considered as the risk factors for the failure to achieve a PASI100 response in psoriasis patients treated with biologics.
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