Protocatechuic Aldehyde Attenuates UVA-induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-kappa B Signaling Pathwaysopen access
- Authors
- Ding, Yuling; Jiratchayamaethasakul, Chanipa; Lee, Seung-Hong
- Issue Date
- Jul-2020
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- ultraviolet A; protocatechuic aldehyde; photoaging; matrix metalloproteinases-1; anti-inflammatory; human dermal fibroblast cells
- Citation
- International Journal of Molecular Sciences, v.21, no.13
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 21
- Number
- 13
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2679
- DOI
- 10.3390/ijms21134619
- ISSN
- 1661-6596
1422-0067
- Abstract
- Ultraviolet radiation (UV) is a major causative factor of DNA damage, inflammatory responses, reactive oxygen species (ROS) generation and a turnover of various cutaneous lesions resulting in skin photoaging. The purpose of this study is to investigate the protective effect of protocatechuic aldehyde (PA), which is a nature-derived compound, against UVA-induced photoaging by using human dermal fibroblast (HDF) cells. In this study, our results indicated that PA significantly reduced the levels of intracellular ROS, nitric oxide (NO), and prostaglandins-E-2(PGE(2)) in UVA-irradiated HDF cells. It also inhibited the levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. Besides, PA significantly suppressed the expression of matrix metalloproteinases-1 (MMP-1) and pro-inflammatory cytokines and promoted collagen synthesis in the UVA-irradiated HDF cells. These events occurred through the regulation of activator protein 1 (AP-1), nuclear factor-kappa B (NF-kappa B), and p38 signaling pathways in UVA-irradiated HDF cells. Our findings suggest that PA enhances the protective effect of UVA-irradiated photoaging, which is associated with ROS scavenging, anti-wrinkle, and anti-inflammatory activities. Therefore, PA can be a potential candidate for the provision of a protective effect against UVA-stimulated photoaging in the pharmaceutical and cosmeceutical industries.
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Collections - College of Medical Sciences > Department of Pharmaceutical Engineering > 1. Journal Articles
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