Comparative study on biodegradation and biocompatibility of multichannel calcium phosphate based bone substitutes
- Authors
- Kang, Hoe-Jin; Makkar, Preeti; Padalhin, Andrew R.; Lee, Gun-Hee; Im, Soo-Bin; Lee, Byong-Taek
- Issue Date
- May-2020
- Publisher
- Elsevier BV
- Keywords
- Multichannel; BCP; TCP; Biodegradation; Bone substitute
- Citation
- Materials Science and Engineering: C, v.110
- Journal Title
- Materials Science and Engineering: C
- Volume
- 110
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2883
- DOI
- 10.1016/j.msec.2020.110694
- ISSN
- 0928-4931
1873-0191
- Abstract
- The objective of this study was to fabricate multichannel biphasic calcium phosphate (BCP) and beta-tricalcium phosphate (TCP) bone substitutes and compare their long-term biodegradation and bone regeneration potentials. Multi-channel BCP and TCP scaffolds were fabricated by multi-pass extrusion process. Both scaffolds were cylindrical with a diameter of 1-mm, a length of 1-mm, and seven interconnected channels. Morphology, chemical composition, phase, porosity, compressive strength, ion release behavior, and in-vitro biocompatibility of both scaffolds were studied. In-vivo biodegradation and bone regeneration efficacies of BCP and TCP were also evaluated using a rabbit model for 1 week, 1 month, and 6 months. BCP exhibited superior compressive strength compared to TCP scaffold. TCP showed higher release of both calcium ions and phosphorous ions than BCP in SBF solution. Both scaffolds showed excellent in-vitro biocompatibility and upregulated the expression of osteogenic markers of MC3T3-E1 cells. In-vivo studies revealed that both cylindrical TCP and BCP scaffolds were osteoconductive and supported new bone formation. Micro-CT data showed that the bone-regeneration efficacy of TCP was higher at one month and at six months after implantation. Histological examination confirmed that TCP degraded faster and had better bone regeneration than BCP after 6 months.
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Collections - College of Medicine > Department of Regenerative Medicine > 1. Journal Articles
- College of Medicine > Department of Neurosurgery > 1. Journal Articles
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