Age-associated changes in chronic rhinosinusitis endotypes
- Authors
- Ryu, Gwanghui; Dhong, Hun-Jong; Park, Minsu; Hwang, Na Young; Kim, Dong-Kyu; Kim, Hyo Yeol; Chung, Seung-Kyu; Rhee, Chae-Seo; Cho, Seong-Ho; Hong, Sang Duk; Kim, Dae Woo
- Issue Date
- May-2020
- Publisher
- Blackwell Publishing Inc.
- Keywords
- age; cytokine; endotype; rhinosinusitis
- Citation
- Clinical and Experimental Allergy, v.50, no.5, pp 585 - 596
- Pages
- 12
- Journal Title
- Clinical and Experimental Allergy
- Volume
- 50
- Number
- 5
- Start Page
- 585
- End Page
- 596
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2894
- DOI
- 10.1111/cea.13586
- ISSN
- 0954-7894
1365-2222
- Abstract
- Background Immunologic function in innate and adaptive immunity changes with the ageing process. Thus, age-related cytokine profiles in chronic rhinosinusitis (CRS) need to be investigated for precision medicine. Objective The objective of this study was to characterize age-related changes in immunologic profiles according to CRS subtypes. Methods Subjects in control (n = 29), CRS without nasal polyps (CRSsNP, n = 86), and CRS with nasal polyps (eosinophilic NP: ENP, n = 81; non-eosinophilic NP: NENP, n = 113) were enrolled in this study. Twenty markers for type 1/2/3 inflammation and other inflammatory processes were measured in homogenates of sinonasal tissues and statistically analysed. Results In control tissues, type 2/3 and proinflammatory mediators showed an inverse correlation with age. CRSsNP and NENP showed an age-related increase in type 2 cytokines and a decline in type 3 cytokines. Interestingly, the age-related decrease in type 3 mediators was associated with those of CT scores in NENP. ENP showed an age-related increase in type 3 cytokines with type 2 mediators sustained at high levels. Smokers with ENP demonstrated age-associated increases in type 1/2/3 mediators as well as CT scores. These age-related patterns in each CRS were confirmed by statistically adjusting atopy status, smoking history, and disease duration. Conclusion Age-associated cytokine changes differed among CRS subtypes and control tissues. CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 mediators, whereas type 3 mediators increased with age in ENP.
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Collections - College of Medicine > Department of Otorhinolaryngology > 1. Journal Articles
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