Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injuryopen access
- Authors
- Yu, Byung Chul; Cho, Nam-Jun; Park, Samel; Kim, Hyoungnae; Gil, Hyo-Wook; Lee, Eun Young; Kwon, Soon Hyo; Jeon, Jin Seok; Noh, Hyunjin; Han, Dong Cheol; Moon, Ahrim; Park, Su Jung; Kim, Jin Kuk; Hwang, Seung Duk; Choi, Soo Jeong; Park, Moo Yong
- Issue Date
- Jan-2020
- Publisher
- MDPI AG
- Keywords
- glomerular filtration rate; glomerulonephritis; minor glomerular abnormalities; mitochondrial injury; urinary mitochondrial DNA
- Citation
- Journal of Clinical Medicine, v.9, no.1
- Journal Title
- Journal of Clinical Medicine
- Volume
- 9
- Number
- 1
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3234
- DOI
- 10.3390/jcm9010033
- ISSN
- 2077-0383
- Abstract
- Minor glomerular abnormalities (MGAs) are unclassified glomerular lesions indicated by the presence of minor structural abnormalities that are insufficient for a specific pathological diagnosis. The long-term clinical outcomes and pathogenesis have not been examined. We hypothesized that MGAs would be associated with the deterioration of long-term kidney function and increased urinary mitochondrial DNA (mtDNA) copy numbers. We retrospectively enrolled patients with MGAs, age-/sex-/estimated glomerular filtration rate (eGFR)-matched patients with immunoglobulin A nephropathy (IgAN), and similarly matched healthy controls (MHCs; n = 49 each). We analyzed the time x group interaction effects of the eGFR and compared mean annual eGFR decline rates between the groups. We prospectively enrolled patients with MGAs, age- and sex-matched patients with IgAN, and MHCs (n = 15 each) and compared their urinary mtDNA copy numbers. Compared to the MHC group, the MGA and IgAN groups displayed differences in the time x group effects of eGFR, higher mean annual rates of eGFR decline, and higher urinary mtDNA copy numbers; however, these groups did not significantly differ from each other. The results indicate that MGAs are associated with deteriorating long-term kidney function, and mitochondrial injury, despite few additional pathological changes. We suggest that clinicians conduct close long-term follow-up of patients with MGAs.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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