Particulate matter at third trimester and respiratory infection in infants, modified by GSTM1
- Authors
- Yang, Song-I; Kim, Hyo-Bin; Kim, Hwan-Cheol; Lee, So-Yeon; Kang, Mi-Jin; Cho, Hyun-Ju; Yoon, Jisun; Jung, Sungsu; Lee, Eun; Yang, Hyeon-Jong; Ahn, Kangmo; Kim, Kyung Won; Shin, Youn Ho; Suh, Dong In; Hong, Soo-Jong
- Issue Date
- Jan-2020
- Publisher
- John Wiley & Sons Inc.
- Keywords
- GSTM1; particulate matter; prenatal; respiratory tract infections; third trimester
- Citation
- Pediatric Pulmonology, v.55, no.1, pp 245 - 253
- Pages
- 9
- Journal Title
- Pediatric Pulmonology
- Volume
- 55
- Number
- 1
- Start Page
- 245
- End Page
- 253
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3276
- DOI
- 10.1002/ppul.24575
- ISSN
- 8755-6863
1099-0496
- Abstract
- Objectives To investigate the association between particulate matter with an aerodynamic diameter of less than 2.5 mu m (PM2.5) exposure during each trimester of pregnancy and development of lower respiratory tract infections (LRTIs) during the first 3 years of life and whether GSTM1 gene polymorphisms modify these effects. Methods This study included 1,180 mother-child pairs from the Cohort for Childhood Origin of Asthma and allergic diseases. The PM2.5 levels during pregnancy were estimated by residential address using land-use regression models based on a national monitoring system. A diagnosis of LRTIs was based on a parental report of a physician's diagnosis. Real-time polymerase chain reaction was used for GSTM1 genotyping. Results Higher PM2.5 exposure during the third trimester was associated with LRTIs at 1 year of age (aRR, 1.06; 95% CI, 1.00-1.13). This result did not change after adjusting for PM2.5 exposures during the first and second trimesters (aRR, 1.06; 95% CI, 0.99-1.13). This association was significant after adjusting for PM2.5 exposures during first year of age (aRR, 1.08; 95% CI, 1.02-1.15) and exposures to NO2 and ozone at the third trimester (aRR, 1.07; 95% CI, 1.00-1.16). In addition, PM2.5 exposure during the third trimester increased the risk of LRTIs at 1 year of age in cases with the GSTM1 null genotype (aRR, 1.26; 95% CI, 1.01-1.57; P for interaction .20). Conclusion Higher PM2.5 exposure during the third trimester of pregnancy may increase the susceptibility to LRTIs at 1 year of age. This effect is modified by GSTM1 gene polymorphisms.
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Collections - College of Medicine > Department of Pediatrics > 1. Journal Articles
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